Trifluoromethylation has been a long-standing challenge for chemists, particularly for compounds containing additional functionality. Most trifluoromethylation methods require harsh conditions, and the reaction scope is limited.
A new broadly-useful method for trifluoromethylation of aryl and vinyl iodides was recently developed by Professor John Hartwig and co-workers at the University of Illinois. Using a copper phenanthroline CF3 reagent, almost any aryl or vinyl iodide can be trifluoromethylated in high yield. The conditions are remarkably mild: ambient temperature and pressure. The reagent is stable enough to be weighed out on the bench top, and no special apparatus such as a glove box is required. The structure of the reagent is shown below.
The Catylix trifluoromethylation reagent is now available from Aldrich: http://www.adlrich.com/catylix
The details were recently published by the Hartwig group:
Angewandte Chemie International Edition
Volume 50, Issue 16, pages 3793–3798, April 11, 2011
The basic reaction using the Cu(phen)CF3 reagent, along with some examples of the reaction scope and functional group compatibility, is shown below:
Catylix has been issued an exclusive, world-wide license from the University of Illinois to the intellectual property covering the trifluoromethylation reagent and its applications for chemical synthesis.
For more information or to learn how to purchase the new Catylix trifluoromethylation reagent, please contact the company CEO David Rozzell: email@example.com