New Hartwig Trifluoromethylation Reagent With Broad Scope Now Available

Catylix has launched its first product: the new reagent for trifluoromethylation of aryl and vinyl iodides developed by John Hartwig and co-workers at the University of Illinois:

 

Branded as Trifluoromethylator®, a new trifluoromethylation reagent, offers chemists exceptional reaction scope and functional group compatibility. The Hartwig trifluoromethylation reagent is now available from Aldrich Chemical Co.:

http://www.aldrich.com/catylix

The trifluoromethyl group is an important functional group for optimizing the properties of pharmaceutical and agricultural lead compounds, often improving bioavailability, bioactivity, and metabolic stability. Previously available methods for the addition of CF3 groups require harsh conditions and have limited applicability due to high cost and the narrow range of compounds that are can be successfully trifluoromethylated.  Composed simply of CF₃, a Cu atom, and a phenanthroline ligand, the reagent is prepared from relatively inexpensive starting materials, offering advantages in cost as well as the benefit of exceptionally broad reaction scope. Trifluoromethylator® is stable enough to be weighed out on the bench-top, and the trifluoromethylation reaction can be carried out near room temperature and without the need of a glove box.

Advantages of CF₃(phen)Cu

• Stable

• Storable

• Weighable on the benchtop

• Requires no glove box or special equipment

 Substrates can

• be electron-rich or electron poor 

• contain protic or electrophilic functionality

• contain one or two substituents ortho to the iodide

 

Trifluoromethyl(1,10-phenanthroline) copper, the Hartwig trifluoromethylation reagent is available commercially from Sigma-Aldrich

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Trifluoromethyl(1,10-phenanthroline) copper, the Hartwig trifluoromethylation reagent is available commercially from Sigma-Aldrich